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Home - Products - Chromatin/Epigenetic - Bromodomain - JQ-1 carboxylic acid

JQ-1 carboxylic acid

CAS No. 202592-23-2

JQ-1 carboxylic acid ( +)-JQ-1 carboxylic acid )

Catalog No. M13156 CAS No. 202592-23-2

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JQ-1 carboxylic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
  • Description
    JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones; a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
  • Synonyms
    +)-JQ-1 carboxylic acid
  • Pathway
    Chromatin/Epigenetic
  • Target
    Bromodomain
  • Recptor
    Bromodomain
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    202592-23-2
  • Formula Weight
    400.88
  • Molecular Formula
    C19H17ClN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    O=C(O)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
  • Chemical Name
    6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.
3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.
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