Cart
sales@molnova.com
Home - Products - Chromatin/Epigenetic - Bromodomain - JQ-1 carboxylic acid

JQ-1 carboxylic acid

CAS No. 202592-23-2

JQ-1 carboxylic acid ( +)-JQ-1 carboxylic acid )

Catalog No. M13156 CAS No. 202592-23-2

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 58 In Stock
10MG 72 In Stock
25MG 111 In Stock
50MG 147 In Stock
100MG 222 In Stock
200MG 335 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    JQ-1 carboxylic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
  • Description
    JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones; a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
  • Synonyms
    +)-JQ-1 carboxylic acid
  • Pathway
    Chromatin/Epigenetic
  • Target
    Bromodomain
  • Recptor
    Bromodomain
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    202592-23-2
  • Formula Weight
    400.88
  • Molecular Formula
    C19H17ClN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    O=C(O)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
  • Chemical Name
    6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.
3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BRD4 inhibitor Compo...

    BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.

  • SGC-iMLLT

    SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively.

  • ABBV-744

    ABBV-744 (ABBV744) is a potent, BDII-selective BET bromodomain inhibitor.

Sign In Join Free